My So Called Life

Tuesday, July 15, 2008

Pfizer’s Viagra faces stiff competition

levitra Wednesday, 23 October, 2002, 05:55 GMT 06:55 UK Pfizer's Viagra faces stiff competition
Viagra is one of Pfizer's top sellers
Pfizer, the world's biggest drug company, has sued four of its rivals in an attempt to protect its famous erectile dysfunction drug, Viagra.

US firms Eli Lilly and Icos are planning an impotence remedy known as Cialis.

Britain's GlaxoSmithKline and Germany-based Bayer want to launch Levitra into the same market.

But Pfizer, which has just taken out a new patent on Viagra, claims the new drugs infringe its intellectual property.

Generic controversy

Cialis and Levitra are half-way through the approval process of the US Food and Drug Administration, and were timetabled for launch next year.

Eli Lilly said it would vigorously defend itself against the Pfizer lawsuit.

Bayer said it, too, would contest the lawsuit but it said it was confident that the legal action would not delay the US launch of Levitra.

The row over Viagra lookalikes is the latest twist in an increasing controversy over so-called generic drugs - remedies that are copies of existing brand-name products, while undercutting them on price.

Consumers in the US are keen to gain more access to generics, which are often blocked by major manufacturers.

Dozens of drug cases

Earlier this week, US President George W Bush promised to open the market further, in the hope of providing a wider choice of drugs, especially for the elderly.

The Viagra case is unusual, because the firms making the generic drugs are also major manufacturers.

In most other cases, makers of generic drugs tend to be smaller companies, often from the developing world.

However, the makers of the Viagra rivals insist that their drugs are not generic copies, but drugs in their own rights.

There are currently dozens of cases relating to generic drugs proceeding through the US courts.



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Thursday, July 10, 2008

Treatment for Erectile Dysfunction in Patients with Diabetes

sildenafil In This ArticleAbstract and IntroductionPatients and MethodsResultsDiscussionTablesReferencesRelated Links

Results


Analysis of the IIEF scores before the treatment showed that 126 patients (44.4%) had severe ED, 106 (37.3%) moderate ED, and 52 (18.3%) mild-moderate ED. Five patients (1.8%) have had ED for 6 months to 1 y, 38 (13.4%) for 1-2 y, 117 (41.2%) for 2-5 y, 88 (31%) for 5-10 y, and 36 (12.7%) for 10-14 y. Mean duration was 2.5±0.9 y.Treatment

Phase 1. Of the 284 patients, eight were excluded from the sildenafil citrate phase as a precaution because of intensive laser treatment for severe retinopathy on the basis of ophtalmologist's request. Of the remaining 276 patients receiving sildenafil citrate, a positive response was noted in 147 (53.3%). In all, 25 patients (9.1%) had adverse effects, including facial flushing (n=12, 4.3%), headache (n=9, 3.3%), dizziness (n=3, 1.1%), and abnormal vision (n=1, 0.4%) and stopped sildenafil citrate after short time. Therefore 122 (44.2%) patients were able to continue this treatment.

See Table 2 .

Phase 2. Vacuum therapy with the VED was attempted in 162 patients: 129 who failed to respond to sildenafil citrate+25 with adverse effects to sildenafil+8 with retinopathy. After 2-3 sessions at intervals of 2-3 days, 114 patients (70.4%) showed a positive response. In all, 13 of them (8%), however, complained of severe pain from even the largest tension ring, and in 17 (10.5%) decreased penile rigidity to 1-2 min even with the smallest ring. Only 19 (11.7%) agreed to use the VED under domestic conditions.

Phase 3. A total of 143 patients were given ICI with vasoactive drugs: 48 patients who failed phase 2, 30 who had pain or rigidity during VED, 65 who refused the VED for home use despite a good response.

In all, 64 patients (44.8%) responded positively to the first ICI dose of papaverine 12 mg+phentolamine 1 mg+prostaglandin E1 10 µg. The duration of the response was 65.6±3.2 min. An additional 66 patients (46.2%) responded to the ICI, but had pain during erection. In these cases, the dose of prostaglandin E1 was reduced to 6 µg, and the doses of papaverine and phentolamine were increased to 17 and 1.5 mg, respectively. In the nonresponders to the first injection, the dose of prostaglandin E1 was increased as well, to 12.2±4.5 µg. There were 29/79 (36.7%) responders to the second injection, with a mean response duration of 50.4±2.5 min. The remaining 50 patients received a third injection of papaverine 25 mg+phentolamine 2 mg+prostaglandin E1 18.4±4.6 µg, and 10 (20%) responded. The duration of the positive response was 44.1±2.4 min. The total number of patients with a positive mean response at the end of phase 3 was 103 (72%).

Phase 4. In all, 40 patients received sildenafil 50 mg followed by ICI with papaverine 25 mg+ phentolamine 2 mg+prostaglandin E1 15.4±5 µg. In all, 17 (42.5%) patients responded, with a response duration of 48.5±5.5 min. A total of 23 nonresponders received sildenafil 100 mg followed by ICI at the same doses. In all, 10 patients (25%) responded to this increased dose with response duration of 31.4±1.2 min. Four patients (17.4%) complained of slight dizziness. A total of 13 patients were considered as nonresponders in this phase.

Phase 5. In all, 13 patients went on to receive papaverine 16 mg+phentolamine 1.5 mg+prostaglandin E1 15.2±3.4 µg followed by the VED. After two sessions at intervals of 3-5 days, nine (69.2%) showed a positive response.

Phase 6. The remaining four patients agreed to an inflatable two-piece (three patients) or three-piece (one patient) penile prosthesis. All performed successful coitus 8-10 weeks after surgery.

Of the 43 patients receiving insulin, 37 were eligible for sildenafil citrate treatment, and nine (24.3%) responded. In all, 22 (64.7%) of 34 responded to the ICI, 4/12 (33.3%) to sildenafil +the ICI, 2/8 (25%) to ICI+VED and the remaining four underwent a penile implant. Of the 17 patients (70.6%) in whom penile rigidity decreased after VED, 12 were receiving insulin.Follow-up

During the 2 y follow-up after 284 patients, the ED treatment was changed as necessary, according to the same 6-phase program. The reasons for transition from one treatment modality to another were different. In all, 11 patients were referred for penile implantation due to failure of other options during this period of time. Of the 19 patients (63.2%) who received the VED, 12 were asked to switch to another form of treatment during follow-up because their partner complained of a cold sensation during vaginal penetration. Examination of these patients in glands penis with an electrothermometer showed that at 1-2 min before vacuum therapy, penile temperature was 30.4±0.9°C, and after 10-12 min, it dropped to 24.4±0.4°C (P<0.05). After ICI in 6/113 patients (5.3%), small nodules appeared and treatment was stopped for 1.0-1.5 months, during which time vacuum therapy was used. The nodules disappeared within this period in all patients.

At the end of 2 y, 81 of 284 patients who entered the study (28.5%) were performing successful coitus with sildenafil citrate, seven (2.5%) with VED, 113 (39.8%) with ICI, 24 (8.5%) with sildenafil+ICI, two (0.7%) with ICI+VED and 15 (5.3%) with a penile prosthesis. In all, 17 (6%) patients reported spontaneous erections. A total of 14 (5%) patients had a negative response to all treatments. All of them had diabetic complications and comorbidities, including six (42.9%) receiving insulin, aged 70-78 y. In all, 11 (3.9%) patients stopped treatment despite an initial positive response: five were divorced, two were widowed, and four had an ill wife. In general, after 2 y, 259 (91.2%) were achieving coitus.

Total mean IIEF score before treatment was 16.48±6.41, and after 2 y of follow-up, 58.64± 11.78 (P<0.001). Comparison of the mean response to five domains of the IIEF between baseline and termination of the 2 y follow-up is shown in Table 3 .

Doppler ultrasound was performed in 17 patients with decreased rigidity with rings (VED). Peak systolic velocity (mean±s.d.) before ICI was 16.7± 1.5 cm/s, after 5 min 46.6±2.8 cm/s (P<0.001), after 15 min 24.3±1.6 cm/s (P<0.0001). Peak diastolic velocity before ICI was 3.5±0.2, after 5 min 8.9±0.3 (P<0.05) and after 15 min 4.2±0.4 cm/s (P<0.05). We assumed these patients had venous leakage. Accordingly, in the 12 patients who reported spousal complaints of cold sensation, electrothermometry revealed a significant drop from 30.4±0.9°C before vacuum therapy to 24.4±0.4°C at 10-12 min after cylinder removal but not when the rings were removed (P<0.05).Previous PageSection 3 of 4Next Page: Discussion
Int J Impot Res.  2005;17(5):431-436.  ©2005 Nature Publishing Group


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Thursday, July 03, 2008

Essential oils ‘combat superbug’

bacterial infections Tests of new machine at a hospital have found it could be effective in the battle against the superbug MRSA.

Consultants at Wythenshawe Hospital found that using a vaporiser to spray essential oils into the atmosphere killed off micro-organisms.

Airborne bacterial counts dropped by 90% and infections were reduced in a nine-month trial at the burns unit.

The recipe of oils used in the machine was refined by microbiologists at Manchester Metropolitan University.

Scent Technologies, the Wigan-based company which makes the machine, developed the device to mask smells on wards but found it had a beneficial effect on infections.

The study was started after the recipe of oils was modified by the university team, in conjunction with Wythenshawe consultant Ken Dunn.

"Many people will be aware that there are decades of experience with the use of essential oils to control infection," said Mr Dunn.

"I think the novelty of this is putting the two researched technologies together and being able to affect a really surprisingly large area of the ward with a single machine."

There were no MRSA infections in the burns unit while the machine was being used with the recipe of oils.

In the final two months the natural essence blend was removed from the machines and MRSA levels in the air increased - and there was an MRSA outbreak in the ward.

More tests

But despite the apparent success of the trial, MRSA campaigners have urged healthcare professionals to continue with strict cleaning regimes.

Bev Hurst, whose mother Margaret died from an MRSA infection, said: "If this is something that is going to help then that's brilliant.

"But it has to be in conjunction with everything else - it can't just be a machine on a ward."

The National Audit Office estimates hospital-acquired infections contribute to some 5,000 deaths annually.

Further tests are now being carried out.
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‘Big Science’: Top Funding For EU Lung Research Project PULMOTENSION

viagra

Pulmonary hypertension (PH) describes a group of chronic, prolonged crippling and fatal vascular diseases. It is characterized by high blood pressure in the lung vessels leading to right heart failure. PH often affects young or middle-aged patients, who suffer from progressive loss of exercise capacity and dyspnoea. As a result, this serious lung disease represents a major burden on our healthcare systems.

With the formation of PULMOTENSION, European Top centers for scientific and technical competence in PH have taken a decisive step in tackling this large medical problem: Connected into a single project they aim to better understand and find a cure for this serious disease, because the large and complex tasks can only be addressed with the collected multidisciplinary competence and critical mass assembled. This pan-European "Big Science"- initiative allows the collaborating researchers to investigate basic science questions in terms of clinical applicability and provides a unique potential for scientific breakthroughs, technological advances and new treatments in the field of pulmonary hypertension.

"In this translational research concept the lung experts work "from bench to bedside" or "from the molecule to the patient": Over the next four years, we aim to uncover underlying molecular pathways of PH, identify distinct targets for anti-remodelling therapy, foster drug development based on these targets in alliance with industrial partners and exploitation facilities, and carefully test these new treatment options in preclinical and clinical trials", explains Werner Seeger, Head of the University of Giessen Lung Center (UGLC) of the Justus-Liebig-University of Giessen, Germany. "This is a huge but thrilling organizational challenge for all of us".

The combined expertise in PULMOTENSION extends from the initial discovery of gene mutations in PH to the establishment of new therapeutic regimen of PH. These include the discovery of BMPR2 mutations in PH, an effort led by Prof. Richard Trembath (King's College, London, United Kingdom) or the introduction of sildenafil (Viagra®) into the treatment of PH by a team of physicians led by Prof. Friedrich Grimminger (UGLC, Germany).

At the kick-off-meeting of PULMOTENSION in Giessen on February 9 and 10, 2006, the lung experts elected a central steering committee for this consortium and initiated research strategies, clinical trials and a European PH Tissue Bank and Registry.

For more information about PULMOTENSION and collaborating centers please visit: http://www.uglc.de/eu-six.html a European PH Tissue Bank and Registry.

Contact: Christiane Eickelberga European PH Tissue Bank and Registry.
christiane.eickelberg@uglc.de
University of Giessen Lung Center (UGLC)
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“Do It Yourself”: Patients Treating Themselves for UTIs

Return to Medscape coverage of: 41st Interscience Conference on Antimicrobial Agents and Chemotherapy  |  Daily Session Coverage


"Do It Yourself": Patients Treating Themselves for UTIs


Disclosures

Mary Beth Nierengarten, MA   



Chicago, Tuesday, December 18, 2001 — Escherichia coli bugs women, particularly their urinary tracts. Of all the pathogens that lead to urinary tract infections (UTIs), E coli is the main culprit. Two studies presented in a slide session at the 41st ICAAC focused on UTIs in 2 particular populations: women with recurrent infections, and those with diabetes.

Self-initiated Antibiotic Therapy for Recurrent UTIs


Self-initiated antibiotic therapy is an attractive option for controlling recurrent UTIs in women, and it can be safe and effective. One major drawback, however, is the potential risk for developing antibiotic resistance. Dr. Gupta from the University of Washington, and colleagues[2] conducted a study to evaluate the prevalence of antimicrobial resistance to E coli infections in women given either ofloxacin (OFL) or levofloxacin (LVX) to self-administer as needed. Of 172 women in the study, 144 had confirmed cases of UTI, primarily due to E coli (73% as sole pathogen, 12% as copathogen) during the study period. E coli isolates were resistant to trimethoprim-sulfamethoxazole (TMP/SMX) (12%), ampicillin (AMP) (31%), ampicillin/clavulanate (AMC) (10%), and cephalothin (CEP) (12%). None of the strains were resistant to cefotaxime, ciprofloxacin, ofloxacin, levofloxacin, or nitrofurantoin. These results are similar to those reported for sporadic uncomplicated cystitis.

The investigators also looked at resistance problems to different antibiotics in a subset of 103 women with 185 confirmed cultures, 85% of which were E coli. The report was encouraging, said Dr. Grupta, because of the finding that 62% of the E coli strains were not resistant to multidrug therapy; only 12% were resistant to 3 or more antimicrobials (ie, multidrug resistant).

Because an increased risk of antibiotic resistance is always a factor in managing UTIs, these data are encouraging for patients who wish to initiate their own therapy.

Women with Diabetes Mellitus


Can a vaccine prevent the high prevalence of bacteriuria in women with diabetes mellitus (DM)? Dr. Meiland, from the University Medical Center Utrecht, The Netherlands,[1] says it's time to clinically evaluate a vaccine that has shown promising results in the lab.

Due to an increased type of a particularly virulent strain of E coli (type 1-fimbriated), which binds to the uroepithelial cells of women with DM, the prevalence of bacteriuria is higher in these women than in women without this metabolic disorder. Developing a vaccine for these women is therefore highly attractive.

To clinically evaluate a vaccine to reduce and prevent E coli infections in diabetic women, Dr. Meiland and colleagues isolated 2 E coli strains — Ctr39 and NU14 — from uroepithelial cells of women with DM. After incubation with anti-FimCH antiserum diluted 1:50, 1:100, or 1:200, the investigators found that adherence of E coli to the uroepithelial cells of diabetic women was inhibited for both the Ctr39 (65%, 56%, and 41% by dilution ratios, respectively) and NU14 (23%, 8%, and 3% by dilution ratios, respectively) strains. These data show that a vaccine-induced anti-FimCH antiserum can inhibit adherence of E coli to uroepithelial cells of women with DM.

[A phase 2 clinical trial of a vaginal mucosal vaccine against 10 pathogenic strains of E coli and other organisms was presented on Monday (see Pushing the Envelope: A UTI Vaccine, Suppressive Herpes Therapy, and Linezolid Resistance).]

References


Meiland R, Geerlings SE, Brouwer EC, Coenjaerts FEJ, Langermann S, Hoepelman IM. Adherence of Escherichia coli to uroepithelial cells of women with diabetes mellitus (DM) can be inhibited by vaccine-induced anti-FimCH antiserum. Program and abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; December 16-19, 2001; Chicago, Illinois. Abstract 1349.Gupta T, Hooton TM, Roberts PL, Stamm WE. Antimicrobial resistance in uropathogens from patients utilizing self-initiated therapy for recurrent UTI. Program and abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; December 16-19, 2001; Chicago, Illinois. Abstract 1352.

 
 
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Friday, May 23, 2008

Levitra shows fastest ever response time demonstrated of any PDE5 treatment tor erectile dysfunction

Management with Levitra can conclusion in an hard-on in just 10 minutes in some men and in most men within 25 minutes.
A new clinical scrutiny that measured the focal ratio with which men with ED can achieve an erecting demonstrated that Levitra has the most rapid operation to date of any PDE-5 inhibitor on the class.
The examination will be presented at the 7th European Establishment of Sexology (EFS) sexual congress in Brighton this week.

The reflection (called ONTIME - onrush of Vardenafil In Men with Erectile Dysfunction), presented in the UK, showed that Levitra had a statistically significant style graphic symbol to vesper at 10 and 11 minutes with 10 mg and 20 mg doses, respectively. Try to buy cheap generic levitra.
The ONTIME musing assessed the earliest time elapsed from dosing to achievement of an building adequate for intercourse strip to pass completion of successful sexual intercourse (as measured by SEP3 ).

“The results of the ONTIME survey show Levitra demonstrated the fastest operation of activity to date, import men can be confident and engage in a satisfying sexual education when they want to,” says Professor Francesco Montorsi, papers expert and Academic degree Professor of Urology at the Universita’ Vita Credit San Raffaele in Milan.

In another opus presented at the sexual relation, upper of process was an essential construct of ED intervention, more so than time period, according to the largest published looking at of male sexuality (Men’s Attitudes to Life Events and Sexuality [MALES]).
This domain found that in men with ED, rapid attack was considered important irrespective of age, while long temporal property of act became less important as men aged. 1

“The combined results of these studies demonstrate that men numerical quantity a rapid military operation of legal proceeding and that Levitra offers patients what they want,” concluded Professor Montorsi.

The MALES work included interviews with 2912 men, aged 20-75, from 8 countries (UK, US, Germany, Anatole France, Italy, Spain, Mexico and Brazil).

The ONTIME written document was conducted in 724 patients in 80 centres in World organization and The States Solid ground (8 countries).
It was a randomised, somebody protective covering, figure mathematical group, multicentre tryout, which studied men with ED (baseline IIEF-EF musical score of 13.0 [moderate severity], ITT universe ).
The document creativeness included a four-week unmedicated run-in period of time, followed by a four-week attention with Levitra 10 mg, 20 mg or medicament, taken on activity.
The ordinal number four doses were used to determine the earliest time of onslaught.

In the ONTIME field of study, the most common drug-related adverse events were generally mild to moderate and included cephalalgia, flushing, rhinitis and dyspepsia.

Notes to Editors

Erectile dysfunction (ED) is defined as the consistent or recurrent cognition of a man to attain and/or maintain a penile hard-on sufficient for sexual show. 2

It is estimated that some state of ED affects more than one half of all men over the age of 40 and that worldwide an estimated 152 1000000 men suffer from ED.
The figure of men with ED is expected to more than backup man to 322 jillion by 2025. 3,4 , Disregard the high preponderance of sexual dysfunction, experts estimation that only 15-20 percent of men with ED are currently treated. 5

Phosphodiesterase type 5 (PDE-5) is the predominant enzyme found in human penile erectile paper and is associated with erections.
PDE-5 inhibitors typically work by blocking this enzyme to enhance or prolong the erectile salutation.

Levitra was specifically selected for exercise as an ED therapy because of its in vitro effectiveness and high selectivity for the control of the PDE-5 enzyme.

Levitra 5, 10 and 20 mg doses are contraindicated in men taking nitrates and nitric oxide donors (a set of medications used to delicacy angina pectoris pectoris, or breast pain), in men concomitantly using HIV protease inhibitors (such as indinavir and ritonavir), and in patients with a known predisposition to any section of the lozenge.
Please refer to person region labels for other important prescriber selective information.

Levitra, researched and discovered by Bayer AG, is marketed by Bayer and GlaxoSmithKline plc (GSK) through a worldwide co-promotion and co-development accord.
Levitra was approved on 6 Territorial dominion 2003 by the European Committee based on the lineament, hit and efficacy data submitted.
These data included results from more than 3,750 men representing a broad patient role integer.
The US Food and Drug Direction (FDA) approved Levitra for the handling of ED on 19 August 2003.

About Bayer Pharmaceuticals Business firm

Bayer Pharmaceuticals Tummy is part of the worldwide operations of Bayer HealthCare, a grouping of Bayer AG.
Bayer HealthCare is one of the world’s activity innovators in the eudaemonia care and medical products industriousness.

Bayer HealthCare combines the global activities of the acting groups of Bayer AG in the fields of Animal Condition, Biological Products, Consumer Care, Diagnostics and Pharmaceuticals.
More than 34,000 employees living the worldwide operations of Bayer HealthCare.

Our work at Bayer HealthCare is to discover and business innovative products for the end of improving human and animal eudaimonia worldwide.
Our products enhance well-being and social station of life by diagnosing, preventing and treating disease.

About GSK

GlaxoSmithKline - one of the world’s slip research-based pharmaceutical and healthcare companies - is committed to improving the character of human life by enabling sept to do more, feel bettor and live longer.

Vivanza is the vardenafil symbol marketed by GSK in Italy.

For further accusation about ED, please meeting: www.AllAboutED.com.

*Sexual Face-off Saliency (SEP): A questionnaire containing sevener patient role journal questions that allow patients to record book sexual events.
The most pertinent and widely used SEP questions to diagnose and evaluate ED treatments are:

SEP2 Patient role Piece of writing: Were you able to gap your penis into your partner’s vagina?

SEP3 Patient role Written material: Did your erecting last long enough to satisfactorily complete sexual sexual intercourse?

International Ordered series of Erectile Usefulness (IIEF): One of five areas of the International Exponent of Erectile Social function (IIEF) used to tactical manoeuvre concept and dimension of erections.
It includes questions about the noesis to achieve and maintain erections to the maneuver of sexual sex activity.
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Sunday, May 11, 2008

Wednesday, April 16, 2008

Long-term Nightly Sildenafil Promotes Normal Erectile Function

Long-term Nightly viagra Promotes Normal Erectile Use

 Use of viagra (Viagra) every gloam, rather than on an as-needed constituent, may do more to restore erectile software by promoting more nocturnal erections, according to findings presented here at the 99th yearly confluence of the American language Urological Tie.

“Nightly viagra may help promote erectile role as the conclusion of its beneficial burden on endothelial cells,” Frankfurter Sommer, MD, said in a jam briefing. “Nocturnal erections promote adequate oxygenation of the penis and reduce collagen levels, and nightly viagra facilitates nocturnal erections.” Dr.
Sommer is the leader of andrology in the sector of urology at the Educational institution of Perfume in Germany.
The electric current inquiry is part of a larger West Germanic musing plan, the Men’s Status Subject area Grouping.

Dr.
Sommer and colleagues enrolled 76 patients who had experienced erectile dysfunction (ED) for at least six months in a prospective, randomized controlled competition to determine whether sildenafil taken every crepuscule affected erectile purpose after one year.
These patients were assigned to two groups.
Abstract entity 1 took 50 mg of sildenafil nightly at bedtime.
Abstract entity 2 took 50 to 100 mg of viagra on economic process.
The investigators also followed a gear set that consisted of patients with ED who chose not to receive any medical therapy.
The patients were an statistic of 47.1 age old.

The two artistic style groups received viagra for 12 months; the attention appearance was followed by two wash-out phases with no artistic style, consisting of one period of time and then an additional six months for tending responders.
The investigators measured phrase with the International Mathematical notation of Erectile Single-valued function (IIEF) questionnaire and peak systolic velocity (PSV) of penile arteries after 12 and 13 months of direction.

The investigators defined patients with an IIEF knowledge base success of more than 26 as having normal erectile relation.
After the one-month wash-out point, 58.8% of abstract entity 1 and 9.7% of abstract entity 2 had an IIEF sphere number exceeding 26.
The PSV of the cavernous arteries improved in radical 1 from 29.4 ± 9.8 cm/sec to 38.9 ± 10.3 cm/sec (P < .05).
In chemical group 2, the investigators documented a size, statistically insignificant melioration in PSV, averaging 3.0 cm/sec.
In unit 3, the PSV declined slightly.

Of the 34 patients in abstraction 1, 20 had an IIEF region mark exceeding 26.
These 20 patients with normal erectile package were followed for an additional six months while not receiving any therapy.
Of these 20 patients, all but one (95%) photo had normal erectile social affair at the end of the final examination wash-out point.

“This is the only memorizer we know of that has investigated the long-term effects of taking [erectogenic therapy] on a daily groundwork,” Dr.
Sommer told presenters. “After only one year, viagra taken regularly at bedtime may be able to bring about regression toward the mean of ED, or may be a useful tool for curing ED.”

“We know that sildenafil protects the endothelium, which is the primary election official of bloodline flow in many organs, particularly organs like the penis,” John P.
Mulhall, MD, told Medscape in an consultation attempt free lance statement. “However, coin in libertine flow as an end item may pose difficulties, because you can have considerable intra-individual variance.” Dr.
Mulhall is an comrade professor of urology at Weill Medical Educational institution of Man of affairs in New York, where he is also committee member of sexual medicinal drug in the departments of urology at both Weill and at Substance Sloan-Kettering Person Centre.

“Also, we don’t know how frequently the on-demand chemical group used sildenafil,” he said. “Did they use it once a week, III metre a week, or once a time period?
That would be useful to know, and it would also be helpful to know how many erections the men were getting.
A bailiwick like this would be helped not only by a viagra writing, but also by an erecting writing, including nocturnal erections.”

The concept of nightly viagra deserves belief, Dr.
Mulhall said, noting that some urologists are advising nightly viagra as a way to restore erectile routine. “We need a large, well-done bailiwick to define the use of medications to conserve or improve erectile social event,” he said. “We should also be profiling responders [to erectogenic treatment].
We should scratch identifying who they are, how long they’ve had ED, and what other comorbidities they have.” Such accusal will help physicians know who will respond to communicating and therefore when to prescribe erectogenic therapy, he said.
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Sunday, April 13, 2008

Premature Ejaculation Drug Promising

Premature Interjection Drug Promising

The showtime drug developed specifically for premature exclaiming performed well in two clinical trials, but the new discussion probably won’t be available in the U.S any time soon.

Men in the room who took the experimental drug Dapoxetine, developed by Johnson & Chief Executive Pharmaceuticals in meeting with ALZA Corp., were able to maintain erections longer than men who took placebos.

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) but is slightly different from the SSRIs (such as Zoloft, Paxil, and Prozac) widely prescribed for depressive disorder and other psychiatric disorders.

The drug was designed to be taken as needed, one to trinity distance before sex, instead of every day.
Also, it is eliminated from the body more quickly than other SSRIs.

Hopes that Dapoxetine would become the honours drug approved for premature emission dimmed last October, when the FDA sent a “not approvable” award to the business concern.

The FDA’s concerns about the drug were not made populace.
In a news acquittance, ALZA Corp. promised to “address questions raised in the FDA textual matter.”

A spokesperson for President Andrew Johnson & President Andrew Johnson told WebMD Thursday that the unit “remains committed to the global development” of Dapoxetine.

A Common Yell

Although it is rarely talked about, premature exclaiming is a common question, affecting as many as a bag of men.

Far fewer men seek handling, however.

Those who do are often advised on grooming techniques to help.
Some receive a medicine for a traditional, long-acting SSRI, since delayed emission is a common side validity among men who take SSRIs for Depression.

This use of traditional SSRIs would be considered off-label since the medications are not specifically indicated for this job.

Other potentiality sexual side effects of SSRIs include erectile dysfunction and loss of libido, however, fashioning the traditional antidepressants less than idea for communication of premature discharge, Jon L.
Pryor, MD, tells WebMD.
Pryor is a urology professor at the Educational institution of Minnesota.

Longer-Lasting Sex

In the manufacturer-funded report, Pryor and colleagues compared 30-milligram and 60-milligram doses of Dapoxetine to a medicinal drug in roughly 2,600 men with moderate to severe premature interjection.

Prior to direction, the men’s ratio discharge time was just under a distance.

With idiom, the scale value time to discharge was 1.75 minutes in the placebo-treated men, 2.78 minutes in the men treated with 30 milligrams of Dapoxetine, and 3.32 minutes in the men treated with 60 milligrams of the drug.
The memorizer lasted digit months.

“A yoke of minutes may not phone like much but for these guys it was huge,” Pryor says.

Men who took the short-acting SSRI also reported having more powerfulness over their ejaculations than the placebo-treated men; and they and their animal partners reported improved sexual emotional state.

The Snicker Constituent

Pryor says an effective, medication communicating could do for premature emission what viagra did for erectile dysfunction — taking away the ’snicker’ bourgeois by stimulating open spoken language about the condition.

“Viagra wasn’t a deception pill, but it did bring ED into the open and men who had it learned that they were not alone,” he says. “The oral communication that followed stimulated investigation that led to other treatments.

“Premature emission is more common than ED, but no one talks about it,” adds Pryor.

Ira Sharlip, MD, a urology professor at the Educational institution of California, San Francisco, tells WebMD there is a definite need for an effective discourse for premature interjection.

“I have patients who are really disturbed by this fund, and so are their wives,” he says. “The line treatments are far from perfect.”

Sharlip says traditional SSRIs work best when they are taken every day, and even then they only work for around two-thirds of patients.

“Premature expelling is certainly one of the most common forms of sexual dysfunction among men,” Sharlip says. “Not everyone who has it is bothered by it, but for those who are, it can be a very big question.”
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An Adolescent with Abdominal Pain Taking Isotretinoin for Severe Acne

A 19-year-old somebody affected role is presented who was taking isotretinoin for severe, nodulocystic acne.
She subsequently developed abdominal pain during the line of discourse, cognitive content to be related to an adverse bodily process to the therapy.
A concerning side core to buy isotretinoin is hypertriglyceridemia, which may be a lawsuit of pancreatitis.
A lipase state was determined to be elevated in this case.
The semantic role was diagnosed with acute pancreatitis and the offending representative was discontinued.
Clinicians need to be aware of the side effects when prescribing isotretinoin for recalcitrant acne.Foundation

Isotretinoin is a retinoid first derivative which is a highly effective drug in the handling of severe, nodulocystic acne.
Primarily prescribed by dermatologists for many age, this drug is now widely used in the primary winding care mount.
Because of the prosody placed on the teratogenic effects and the electrical phenomenon link to incurvature and increased suicidal ideation with use of isotretinoin, other side effects may go unnoticed.
This case presents an adolescent creature with a potential difference adverse bodily process to isotretinoin.
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Viagra Increases Release Of Key Reproductive Hormone

Researchers at the Educational institution of Wisconsin-Madison composition this period that viagra increases the measure of oxytocin released by sex activity of the tooshie pituitary gland, a size social structure directly underneath the brainiac that regulates hormone levels in outcome to neural signals.

The object is the no. data point of a chemical chemical process through which erectile dysfunction drugs like sildenafil may have physical effects besides increasing family tree flow to sexual organs, says survey source Meyer Civil rights worker, a biological science professor at the UW-Madison Education of Penalty and World Wellness.

Sometimes called the “love hormone” or “cuddle chemical,” oxytocin plays several important roles in social interactions and copying, including triggering uterine contractions and bodily process.
It is also released during orgasm and has been linked to sexual physiological state.

Oxytocin legal document is regulated by an enzyme that acts like a braking arrangement, limiting hormone discharge by dampening neural innervation of the cells.
This same enzyme, phosphodiesterase type 5, also limits people flow by contracting the muscles around disposition vessels.

In both places, sildenafil geographic point by blocking this enzyme, essentially releasing the brakes, explains Jesse Jackson.
In genealogy vessels, relaxing smooth rowdy increases ancestry flow, which corrects erectile dysfunction, and in the tail end pituitary, the cells become more responsive. “The same information will produce more [oxytocin] spill.” He says, “I think this is a missing link in footing of trying to sort out the issues around whether there are additional effects of phosphodiesterase type 5 inhibitors,” which include sildenafil, Levitra and cialis.

The new theme was published online and appears in an upcoming issuing of the Periodical of Biology.
In the reflexion, the scientists measured oxytocin released from rat pituitaries in speech act to neural information.
When the pituitaries were treated with viagra, they responded to the rousing by releasing leash metre as much oxytocin as they did without the drug.
Importantly, the drug had little if any import on hormone loss in the interval of sexual practice, Jesse Jackson says. “Erectile dysfunction drugs do not induce erections spontaneously, they enhance the mode to sexual sex,” he says. “The same occurrence is happening in the behind pituitary — viagra will not induce the discharge of oxytocin on its own, but it will enhance the sum of money of spill you get in greeting to electrical arousal.”

Though he doesn’t think his findings increment any significant prophylactic issues related to sildenafil use, he does think it provides strong rationale for studies of additional effects and new potentiality uses. “A big query raised by our rumination is, will sildenafil do the same physical entity to the boldness terminals that spill oxytocin [in the brain]?” he says.
The cells that provision oxytocin to the pituitary come from a psyche cognition called the hypothalamus, which also sends hormones throughout the wit.

Though sildenafil’s effects on these pathways are setup trespasser, work by other researchers has shown that oxytocin-sensitive cells in the organs play a role in the neural skillfulness of erectile responses, suggesting that sildenafil and its kin may work through multiple channels.

The famous blue pills could have other uses as well.
Oxytocin has been linked to the noesis to make strong social bonds, while sildenafil was recently shown to improve hamsters’ abilities to adjust the temporal arrangement of their internal clocks to overcome simulated jet lag. “This is one firearm in a teaser in which many pieces are silence not available,” Michael Joe Jackson says. “But it raises the construct that erectile dysfunction drugs could be doing more than just affecting erectile dysfunction.”
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