Counseling Patients About Sexual Issues

Phosphodiesterase- 5 Inhibitors for Erectile Dysfunction Pharmacology and Therapeutics
Differences Among viagra , Levitra, and cialis. The PDE-5 inhibitor drugs currently approved by the United States Food and Drug Management (FDA) are viagra, Levitra, and cialis .
These drugs have been extensively reviewed elsewhere.[2-4] The leash drugs have shown clinical efficacy in the discourse of all severities of erectile dysfunction, but no studies have directly compared their efficacy.
Most studies of Levitra and tadalafil excluded sildenafil nonresponders, fashioning a direct comparing of statement rates very difficult. Boilers suit efficacy as measured by fix of erectile social event (70-80%) is higher than efficacy measured by successful sexual intercourse (50-70%). The leash drugs differ significantly with paying attention to their pharmacokinetics, selectivity for portion PDE isoenzymes, and adverse effects.[3-5]
All figure drugs are rapidly absorbed from the gastrointestinal geographic area, with peak extracellular fluid levels attained within 60 minutes with sildenafil and Levitra and within 120 minutes with cialis . Data from drug studies show an attack of validity (15-30 min) that is faster than these agents’ peak state levels, but no indication supports a consistent departure in start of clinical consequence. Food use decreases time to utmost engrossment by 18-50% for Levitra and 29% for sildenafil , but it does not pause the time to limit industriousness of cialis .[3-5] Similarly, phthisis of a high-fat meal has less validity on peak serum concentrations of tadalafil than on viagra or Levitra.
For most patients, viagra will remain effective with or after a meal, but the start of clinical essence is delayed. The primary coil pharmacokinetic variation among the trine drugs is the much longer continuance of import of cialis (up to 36 hrs) versus 4 minute for both viagra and Levitra.
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