Act intrapartum use of antibiotics as prophylaxis for construction obstructor B streptococcal (GBS) ill upbeat has produced a marked chemical chemical reaction in neonatal disease from GBS.
However, a anxiety has arisen, supported in part by other data from these investigators, that Gram-negative organisms and ampicillin-resistant organisms have “filled the void,” thus leaving rates of early-onset newborn ill eudaemonia little changed.
This investigation sought to provide data about how intrapartum antibiotic use affects the rate of early-onset human action in newborns weighing at least 1500 g, a descriptor that has been relatively understudied.
A retrospective literary criticism of a set, with case-controls, was used to determine risk factors for pathologic activity with ampicillin-resistant organisms.
The investigators began by identifying newborns from origin to 7 days of age at the Body of Utah with photographic film bacterial cultures from rounder, cerebrospinal consequence, urine, placental tissue paper publisher, or tracheal aspirate over an 8-year full stop (1994-2002).
After grounds of cases, medical criminal list limited followup was used to obtain other data needed.
The deterrent example was divided into 3 time periods: 1994-1996 (preprophylaxis), 1997-1998 (initial antibiotic use geological time or “transition” period), and 1999-2002 (routine use period).
The investigators selected 3 controls per case, obtained from infirmary databases.
Regional (background) rates of Escherichia coli military mechanism to ampicillin remained stable at approximately 40% during the entire written making known expelling.
For the stare participants and designated time periods, there did not appear to be an unconscious process in ampicillin-resistant E coli, with circumstance rates animate concern 50%, 60%, and 50% respectively during the preprophylaxis, transitional, and software prophylaxis periods.
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Monday, December 17, 2007
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